Yes, That's my garage. I hosed it out really well and used an expensive HVLP gun to minimize overspray. The gun I used has an 85% paint to surface transfer ratio (meaning only 15% of your paint is lost in mist) , which is the best I could find. Also, since I live in AZ, I have the luxury of using really fast flashing reducers because of the low humidity. The reducer went off within 5 minutes after each coat, so I didn't have to worry about dust settling into it.